Synthetic lipids

NucleoSyn produces and supplies synthetic lipids from milligrams to multi-kilos quantities.

DLin-MC3-DMA

CAS #

1224606-06-7

Packing size

100 mg, 500 mg, 1 g, bulk (gram scale)

DLin Nanoparticle

DLin-MC3-DMA is a cationic lipid for siRNA, mRNA, and vaccine delivery. Administration of DLin-MC3-DMA-based LNPs has delivered siRNA to reduce Factor VII levels or leukemic burden in mice. DLin-MC3-DMA can form nanoparticles that can encapsulate and deliver siRNA, mRNA, DNA, or small molecules into the cytoplasm and represent the most advanced delivery platforms for the systemic administration of active molecules.

Related products : [D13]-DLin-MC3-DMA , [13C3]-DLin-MC3-DMA

Aspect

Yellowish oil

Purity

98%

Solubility

DCM, MeOH, Acetone

Molecular weight

642,11

Molecular formula

C₄₃H₇₉NO₂

IUPAC

(6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate

M. Yanez Arteta et al., Proc. Natl. Acad. Sci. U.S.A., 2018, 115, 15, E3351-E3360. read article

J. Viger-Gravel et al., J. Phys. Chem. B, 2018, 122, 7, 2073–2081. read article

K. J. Hassett et al., Molecular Therapy Nucleic Acids, 2019, 15, 1-11. read article

M. Jayaraman et al., Angew. Chem. Int. Ed. Engl., 2012, 51, 34, 8529-8533. read article

R. S. Riley et al., Sci. Adv., 2021, 7, 1-15. read article