Synthetic lipids

NucleoSyn produces and supplies synthetic lipids from milligrams to multi-kilos quantities.

Lipid 5

CAS #

2089251-33-0

Packing size

100 mg, 500 mg, 1 g, bulk (gram scale)

mRNA delivery Nanoparticle

Lipid 5 is an ionizable lipid that can be incorporated in LNPs and used for the delivery of mRNA in primates and rapidly cleared from the body resulting in low toxicity.

Aspect

Yellowish oil

Purity

98%

Solubility

DCM, DMSO

Molecular weight

710,18

Molecular formula

C₄₄H₈₇NO₅

IUPAC

heptadecan-9-yl 8-((2-hydroxyethyl)(8-(nonyloxy)-8-oxooctyl)amino)octanoate

S. Sabnis et al., Mol. Ther., 2018, 26, 6, 1509-1519. read article

L. Ci et al., Drug Metabolism and Disposition, 2023, 51, 7, 813-823. read article

M. Cornebise et al., Adv. Funct. Mater., 2022, 32, 2106727. read article