Synthetic lipids

NucleoSyn produces and supplies synthetic lipids from milligrams to multi-kilos quantities.

Lipid N2-3L

CAS #

2924606-55-1

Packing size

100 mg, 500 mg, 1 g, bulk (gram scale)

Synonyme(s)

Lipid NL

cancer treatment Nanoparticle

Lipid N2-3L is a novel ionizable lipid used in combination with other lipids, such as L-PGTA also provided by Nucleosyn, in the formulation of original LNPs to elaborate new high-performances mRNA cancer vaccines. In the case of supramolecular lipid nanoparticles (SMLNPs) formulation, it has been shown that Lipid N2-3L enhanced the translation efficiency of mRNA. In the presence of β-cyclodextrin, the R848 adjuvant could also be encapsulated in an mRNA vaccine thanks to non-covalent host-guest complexation promoting dendritic cell maturation and antigen presentation after vaccination. It led thus to high in vivo antitumor efficacy boosted by a synergy with immune checkpoint blockade by potentiating the anticancer capability of cytotoxic T lymphocytes infiltrated in tumor sites.

Nucleosyn provides high-quality synthetic lipids for R&D use only.

Aspect

Yellow oil

Purity

98%

Solubility

DMSO, MeOH, EtOH

Molecular weight

840.29

Molecular formula

C₄₈H₉₃N₃O₈

IUPAC

3-(2-((2-hexyldecanoyl)oxy)ethyl)-14-hydroxy-12-(2-hydroxyethyl)-7-oxo-6-oxa-3,8,12-triazatetradecyl oleate

K. Yang et al., J. Am. Chem. Soc., 2024, 146, 17, 11679-11693. (read article)

S. Qi et al., Adv. Mater., 2024, 36, 23, e2311574. (read article)

CN116023303A, 2022. (read article)