3'-Dabsyl-CPG1000

A molecular beacon probe1 has its natural fluorescence quenched in solution unless it is hybridized to the target sequence. Consequently, the design of a molecular beacon requires a fluorophore to be in one part of the sequence and the quencher molecule to be in another, with both molecules being separated from the oligonucleotide by a hydrocarbon spacer. 3'-Dabsyl CPG is used to prepare probes with the quencher blocking the 3'-terminus.