3'-Thiol-Modifier-C3-SS-CPG1000

The 3’-Thiol-Modifier-SS-C3-CPG is used to introduce 3’-thiol linkages with three atom spacers into oligonucleotides. Incorporation of a thiol-reactive functional group at specific sites within an oligonucleotide allows for subsequent post-synthesis conjugation of the oligo with several different moieties such as fluorescent markers and biotin, depending on the application. Such labels need to be reactive towards the incorporated functional group: for example, thiols will react with iodoacetate and maleimide derivatives to form thioether linkages.