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5'-Biotin phosphoramidite

CAS #

135137-87-0

Packing size

50µmol, 100µmol, 250mg

Biotin Phosphoramidite

5’-Biotin phosphoramidite was designed to functionalize the 5’-terminus of the target oligonucleotide. The presence of the DMT group allows the quantification of coupling. Also, the DMT group on biotin phosphoramidite can be used in RP cartridges and HPLC purification techniques.

Aspect

White solid

Purity

>95% (LC)

Solubility

Dichloromethane, EtOAc, MeCN

Molecular weight

846,07

Molecular formula

C₄₆H₆₄N₅O₆PS

IUPAC

6-(5-((3aS,4S,6aR)-1-(bis(4-methoxyphenyl)(phenyl)methyl)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)hexyl (2-cyanoethyl) diisopropylphosphoramidite

C. Riccardi et al., ACS Appl. Mater. Interfaces, 2017, 9, 41, 35574–35587. read article

A. Pasternak et al., Nucleic Acids Research, 2011, 39, 3, 1155-1164. read article

E. E. Ferapontova et al., Chem. Commun., 2010, 46, 1836–1838. read article

R. T. Pon, Tetrahedron Letters, 1991, 32, 14, 1715-1718. read article

5'-Biotin phosphoramidite

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