Stable isotope

Nucleosyn provides Custom Stable Isotope (²H, ¹³C, ¹⁵N) compounds to support projects dedicated to : Bioanalytics, Omics research, Molecular Imaging, and Biomarker discovery.

[13C,15N2]-2',2'-Difluoro-2'-deoxyuridine

CAS #

1233921-75-9

Packing size

5mg, 10mg, 25mg, bulk

Synonyme(s)

[13C,15N2]-dFdU

Anticancer drug Therapeutic Drug Monitoring (TDM)

2',2'-Difluoro-2'-deoxyuridine, also known as dFdU, is the main active metabolite of Gemcitabine, generated by deamination of Gemcitabine by cytidine deaminase in the liver. dFdU is cytotoxic to HepG2 and A549 cancer cells.

Stable isotope labeled [¹³C,¹⁵N₂]-2',2'-Difluoro-2'-deoxyuridine is intended for use as an internal standard for the quantification of 2',2'-Difluoro-2'-deoxyuridine and Dansyl-2',2'-difluoro-2'-deoxyuridine LC or GC-mass spectrometry.

Aspect

White solid

Purity

Chemical purity 95%; Isotopic Enrichment 98%

Solubility

DMSO, DMF, Water, EtOH

Molecular weight

267.16

Molecular formula

C₈¹³CH₁₀F₂¹⁵N₂O₅

IUPAC

1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione-2-13C-1,3-15N2

M. Briki et al., J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2024, 1236, 124039. (read article)

T. Bjanes et al., J. Pharm. Sci., 2015, 104, 12, 4427-4432. (read article)

C. Bowen et al., J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2009, 877, 22, 2123-2129. (read article)

[13C,15N2]-2',2'-Difluoro-2'-deoxyuridine

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