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Stable isotope

Nucleosyn provides Custom Stable Isotope (2H, 13C, 15N) compounds to support projects dedicated to : Bioanalytics, Omics research, Molecular Imaging, and Biomarker discovery.

[13C,15N2]-Cytarabine

Packing size
5mg, 10mg, 25mg, bulk
Anticancer drugTherapeutic Drug Monitoring (TDM)SIL
-Cytarabine Image 1

Cytarabine is a nucleoside analog and antimetabolite used in the treatment of several types of cancers including acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), chronic myelogenous leukemia (CML), and non-Hodgkin's lymphoma. Cytarabine induces serious side effects such as bone marrow suppression, liver problems, ulcer formation in the mouth, loss of consciousness, lung disease or allergic reactions.

Stable isotope labeled [13C,15N2]-Cytarabine is intended for use as an internal standard for the quantification of Cytarabine by LC or GC-mass spectrometry.

Aspect
Crystalline solid
Purity
Chemical purity 95%; Isotopic Enrichment 98%
Solubility
DMSO, DMF, Water
Molecular weight
246.20
Molecular formula

C813CH13N15N2O5

IUPAC
4-amino-1-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one-2-13C-1,3-15N2

M. Briki et al., J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2024, 1236, 124039. (read article)

C. Abbara et al., Cancer Chemother. Pharmacol., 2020, 86, 5, 687-691. (read article)

M. Donnette et al., J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2019, 1126-1127, 121770. (read article)

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