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Stable isotope

Nucleosyn provides Custom Stable Isotope (2H, 13C, 15N) compounds to support projects dedicated to : Bioanalytics, Omics research, Molecular Imaging, and Biomarker discovery.

[13C,15N2]-Gemcitabine hydrochloride

CAS #
1262897-74-4
Packing size
5mg, 10mg, 25mg, bulk
Anticancer drugTherapeutic Drug Monitoring (TDM)SIL
-Gemcitabine hydrochloride Image 1

Gemcitabine is a chemotherapy drug used to treat various cancers, including testicular cancer, breast cancer, ovarian cancer, non-small cell lung cancer, pancreatic cancer, and bladder cancer. Gemcitabine induces multiple side effects such as bone marrow suppression, liver and kidney problems, rash, shortness of breath, neuropathy, and hair loss.

Stable isotope labeled [13C,15N2]-Gemcitabine is intended for use as an internal standard for the quantification of Gemcitabine and Dansyl-gemcitabine by LC or GC-mass spectrometry.

Aspect
White solid
Purity
Chemical purity 95%; Isotopic Enrichment 98%
Solubility
MeOH (heated), Water
Molecular weight
302.64
Molecular formula

C813CH12ClF2N15N2O4

IUPAC
4-amino-1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one-2-13C-1,3-15N2 hydrochloride

M. Briki et al., J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2024, 1236, 124039. (read article)

T. Bjanes et al., J. Pharm. Sci., 2015, 104, 12, 4427-4432. (read article)

C. Bowen et al., J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2009, 877, 22, 2123-2129. (read article)

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