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Stable isotope

Nucleosyn provides Custom Stable Isotope (2H, 13C, 15N) compounds to support projects dedicated to : Bioanalytics, Omics research, Molecular Imaging, and Biomarker discovery.

[13C2,15N]-6-Thioguanine

CAS #
1330266-29-9
Packing size
5mg, 10mg, 25mg, bulk
Synonyme(s)
[13C2,15N]-Tioguanine
Anticancer drugTherapeutic Drug Monitoring (TDM)SIL
-6-Thioguanine Image 1

6-Thioguanine is a purine analog of guanine used to treat acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), and chronic myeloid leukemia (CML). It can also be employed in the treatment inflammatory bowel disease and psoriasis. Long-term use of 6-Thioguanine is not recommended. This drug induces side effects such as leukopenia, neutropenia, thrombocytopenia, anemia, anorexia, and hepatotoxicity.

Stable isotope labeled [13C2,15N]-6-Thioguanine is intended for use as an internal standard for the quantification of 6-Thioguanine by LC or GC-mass spectrometry.

Aspect
Yellowish solid
Purity
Chemical purity 95%; Isotopic Enrichment 98%
Solubility
DMSO
Molecular weight
170.17
Molecular formula

C313C2H5N415NS

IUPAC
2-amino-9H-purine-6-thiol-4,5-13C2-7-15N

M. Briki et al., J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2024, 1236, 124039. (read article)

S. Y. Moon et al., Ther. Drug Monit., 2019, 41, 1, 75-85. (read article)

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