Stable isotope

Nucleosyn provides Custom Stable Isotope (²H, ¹³C, ¹⁵N) compounds to support projects dedicated to : Bioanalytics, Omics research, Molecular Imaging, and Biomarker discovery.

[13C5]-Azacytidine

Packing size

5mg, 10mg, 25mg, bulk

Anticancer drug Therapeutic Drug Monitoring (TDM)

Azacytidine is a chemical analog of cytidine which is used to treat myelodysplastic syndrome (MDS), myeloid leukemia, and juvenile myelomonocytic leukemia (JMML). Common side effects caused by azacytidine are anemia, neutropenia, and thrombocytopenia.

Stable isotope labeled [¹³C₅]-Azacytine is intended for use as an internal standard for the quantification of Azacytidine by LC or GC-mass spectrometry.

Aspect

White powder

Purity

Chemical purity 95%; Isotopic Enrichment 98%

Solubility

DMSO, Water

Molecular weight

249.17

Molecular formula

C₃¹³C₅H₁₂N₄O₅

IUPAC

4-amino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl-2,3,4,5-13C4)-1,3,5-triazin-2(1H)-one-2-13C

M. Briki et al., J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2024, 1236, 124039. (read article)

M. Donnette et al., Cancer Chemother. Pharmacol., 2023, 91, 3, 231-238. (read article)

[13C5]-Azacytidine

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