Stable isotope

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[15N2]-5-Fluorouracil

CAS #

68941-95-7

Packing size

5mg, 10mg, 25mg, bulk

Synonyme(s)

[15N2]-5-FU

Anticancer drug Therapeutic Drug Monitoring (TDM)

5-Fluorouracil (5-FU) is a metabolite of Capecitabine. Capecitabine is converted by carboxylesterase to 5'-Deoxy-5-fluorocytidine in the liver, then by cytidine deaminase to 5’-Deoxy-5-fluorouridine in the liver and tumor tissues, and finally, by thymidine phosphorylase to 5-Fluorouracil in tumors. Formulations containing 5-FU have been used to treat colorectal, breast, gastric and pancreatic cancers.

Stable isotope labeled [¹⁵N₂]-5-Fluorouracil is intended for use as an internal standard for the quantification of 5-Fluorouracil by LC or GC-mass spectrometry.

Aspect

Crystalline solid

Purity

Chemical purity 95%; Isotopic Enrichment 98%

Solubility

Water, EtOH, DMF, DMSO, Chloroform

Molecular weight

132.06

Molecular formula

C₄H₃F¹⁵N₂O₂

IUPAC

5-fluoropyrimidine-2,4(1H,3H)-dione-1,3-15N2

M. Briki et al., J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2024, 1236, 124039. (read article)

B. Reigner et al., Cancer Chemother. Pharmacol., 1999, 43, 4, 309-315. (read article)

B. Buchel et al., Biomed. Chromatogr., 2013, 27, 1, 7-16. (read article)

M. A. Serdar et al., Cancer Chemother. Pharmacol., 2011, 68, 2, 525-529. (read article)

J. E. Kosovec et al., Rapid Commun Mass Spectrom., 2008, 22, 2, 224-230. (read article)

[15N2]-5-Fluorouracil

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