Stable isotope

Nucleosyn provides Custom Stable Isotope (²H, ¹³C, ¹⁵N) compounds to support projects dedicated to : Bioanalytics, Omics research, Molecular Imaging, and Biomarker discovery.

[D8]-Imatinib

CAS #

1092942-82-9

Packing size

5mg, 10mg, 25mg, bulk

Anticancer drug Therapeutic Drug Monitoring (TDM)

Imatinib is a molecule used to treat several types of cancers and diseases, including chronic myelogenous leukemia (CML), acute lymphocytic leukemia (ALL), certain types of gastrointestinal stromal tumors (GIST), hypereosinophilic syndrome (HES), chronic eosinophilic leukemia (CEL), aggressive systemic mastocytosis, and myelodysplastic syndrome. Imatinib is taken by mouth.

Stable isotope labeled [D₈]-Imatinib is intended for use as an internal standard for the quantification of Imatinib, Erlotinib, and Gefitinib by LC or GC-mass spectrometry.

Aspect

Solid

Purity

Chemical purity 95%; Isotopic Enrichment 98%

Solubility

DMSO, DMF, Water

Molecular weight

501.66

Molecular formula

C₂₉H₂₃D₈N₇O

IUPAC

N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl-2,2,3,3,5,5,6,6-d8)methyl)benzamide

J. E. Adaway, B. G. Keevil, J. Chromatogr. B, 2012, 883-884, 33-49. (read article)

A. Chahbouni et al., Ther. Drug Monit., 2009, 31, 683-687. (read article)

A. Awidi et al., Leuk. Res., 2010, 34, 714-717. (read article)

S. De Francia et al., J. Chromatogr. B: Anal. Technol. Biomed. Life Sci., 2009, 877, 1721. (read article)

B. Rochat et al., J. Mass Spectrom., 2008, 43, 736. (read article)

K. Titier et al., Ther. Drug Monit., 2005, 27, 634. (read article)

[D8]-Imatinib

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