Stable isotope

Nucleosyn provides Custom Stable Isotope (²H, ¹³C, ¹⁵N) compounds to support projects dedicated to : Bioanalytics, Omics research, Molecular Imaging, and Biomarker discovery.

[D11]-Capecitabine

CAS #

1132662-08-8

Packing size

5mg, 10mg, 25mg, bulk

Anticancer drug Therapeutic Drug Monitoring (TDM)

Capecitabine is an anticancer drug used to treat breast cancer (advanced or metastatic), gastric cancer (unresectable or metastatic), and colorectal cancer (unresectable or metastatic). It induces serious side effects including blood clotting problems, allergic reactions, and heart problems such as cardiomyopathy and low blood cell counts.

Stable isotope labeled [D₁₁]-Capecitabine is intended for use as an internal standard for the quantification of Capecitabine by LC or GC-mass spectrometry.

Aspect

White powder

Purity

Chemical purity 95%; Isotopic Enrichment 98%

Solubility

DMSO, Water (warmed)

Molecular weight

370.42

Molecular formula

C₁₅H₁₁D₁₁FN₃O₆

IUPAC

pentyl-d11 (1-((3R,4S,5R)-3,4-dihydroxy-5-methyltetrahydrofuran-2-yl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl)carbamate

M. Briki et al., J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2024, 1236, 124039. (read article)

C-J. Wang et al., Adv. Ther., 2021, 38, 9, 4798-4814. (read article)

P. Deng et al., J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2015, 989, 71-79. (read article)

M-J. Deenen et al., J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2013, 913-914, 30-40. (read article)

[D11]-Capecitabine

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