Stable isotope

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[D3]-Vincristine sulfate salt

CAS #

1246817-10-6

Packing size

5mg, 10mg, 25mg, bulk

Synonyme(s)

[D3]-Leurocristine sulfate salt

Anticancer drug Therapeutic Drug Monitoring (TDM)

Vincristine, also known as Leurocristine, is an alkaloid drug used to treat numerous types of cancers, including acute lymphocytic leukemia, acute myeloid leukemia, Hodgkin's disease, neuroblastoma, and small-cell lung cancer. It induces severe side effects such as neuropathic pain, lung damage, and low white blood cells.

Stable isotope labeled [D₃]-Vincristine sulfate salt is intended for use as an internal standard for the quantification of Vincristine by LC or GC-mass spectrometry.

Aspect

White solid

Purity

Chemical purity 95%; Isotopic Enrichment 98%

Solubility

DMSO, Water

Molecular weight

926.06

Molecular formula

C₄₆H₅₅D₃N₄O₁₄S

IUPAC

methyl (3aR,3a1R,4R,5S,5aR,10bR)-4-(acetoxy-d3)-3a-ethyl-9-((5S,7S,9S)-5-ethyl-5-hydroxy-9-(methoxycarbonyl)-1,4,5,6,7,8,9,10-octahydro-2H-3,7-methano[1]azacycloundecino[5,4-b]indol-9-yl)-6-formyl-5-hydroxy-8-methoxy-3a,3a1,4,5,5a,6,11,12-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylate sulfate

M. Briki et al., J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2024, 1236, 124039. (read article)

Z. Yan et al., Acta. Pharmacol. Sin., 2012, 33, 6, 852-858. (read article)

[D3]-Vincristine sulfate salt

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