Stable isotope

Nucleosyn provides Custom Stable Isotope (²H, ¹³C, ¹⁵N) compounds to support projects dedicated to : Bioanalytics, Omics research, Molecular Imaging, and Biomarker discovery.

[D5]-6-Alpha-hydroxy-paclitaxel

CAS #

1315376-90-9

Packing size

5mg, 10mg, 25mg, bulk

Anticancer drug Therapeutic Drug Monitoring (TDM)

6-Alpha-hydroxy-paclitaxel is a metabolite of the anticancer drug Paclitaxel. It is formed from paclitaxel by the cytochrome P450 (CYP) isoform CYP2C8.

Stable isotope labeled [D₅]- 6-Alpha-hydroxy-paclitaxel is intended for use as an internal standard for the quantification of 6-Alpha-hydroxy-paclitaxel by LC or GC-mass spectrometry.

Aspect

Crystalline solid

Purity

Chemical purity 95%; Isotopic Enrichment 98%

Solubility

DMSO, MeOH

Molecular weight

858.95

Molecular formula

C₄₇H₄₆D₅NO₁₅

IUPAC

(2aR,3S,4R,4aS,6R,9S,11S,12S,12aR,12bS)-9-(((2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl)oxy)-12-((benzoyl-2,3,4,5,6-d5)oxy)-3,4,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-3,4,4a,5,6,9,10,11,12,12a-decahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxete-6,12b(2aH)-diyl diacetate

M. Briki et al., J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2024, 1236, 124039. (read article)

S. M. Christner et al., J. Pharm. Biomed. Anal., 2019, 172, 26-32. (read article)

[D5]-6-Alpha-hydroxy-paclitaxel

Purchase [D5]-6-Alpha-hydroxy-paclitaxel

Get a quote on this product

Related products