Stable isotope

Nucleosyn provides Custom Stable Isotope (²H, ¹³C, ¹⁵N) compounds to support projects dedicated to : Bioanalytics, Omics research, Molecular Imaging, and Biomarker discovery.

[D6]-Cabazitaxel

CAS #

1383561-29-2

Packing size

5mg, 10mg, 25mg, bulk

Anticancer drug Therapeutic Drug Monitoring (TDM)

Cabazitaxel is a semi-synthetic derivative of a natural taxoid used in combination with Prednisone to treat metastatic castration-resistant prostate cancer.

Stable isotope labeled [D₆]-Cabazitaxel is intended for use as an internal standard for the quantification of Cabazitaxel by LC or GC-mass spectrometry.

Aspect

White solid

Purity

Chemical purity 95%; Isotopic Enrichment 98%

Solubility

DMSO

Molecular weight

841.98

Molecular formula

C₄₅H₅₁D₆NO₁₄

IUPAC

(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-bis(methoxy-d3)-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate

M. Briki et al., J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2024, 1236, 124039. (read article)

P. de Bruijn et al., J. Pharm. Biomed. Anal., 2012, 59, 117-122. (read article)

[D6]-Cabazitaxel

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