Stable isotope

Nucleosyn provides Custom Stable Isotope (²H, ¹³C, ¹⁵N) compounds to support projects dedicated to : Bioanalytics, Omics research, Molecular Imaging, and Biomarker discovery.

[D8]-Busulfan

CAS #

116653-28-2

Packing size

5mg, 10mg, 25mg, bulk

Anticancer drug Therapeutic Drug Monitoring (TDM)

Busulfan is a non-specific alkylating antineoplastic agent used to treat chronic myeloid leukemia, other leukemias, lymphomas, and myeloproliferative disorders. This alkylating agent forms DNA-DNA guanine/adenine or guanine/guanine interstrand crosslinks. Busulfan can be taken by mouth or given into a vein.

Stable isotope labeled [D₈]-Busulfan is intended for use as an internal standard for the quantification of Busulfan by LC or GC-mass spectrometry.

Aspect

Solid

Purity

Chemical purity 95%; Isotopic Enrichment 98%

Solubility

Acetone, MeOH, EtOH, Water (hydrolysis)

Molecular weight

254.34

Molecular formula

C₆H₆D₈O₆S₂

IUPAC

butane-1,4-diyl-d8 dimethanesulfonate

J. E. Adaway, B. G. Keevil, J. Chromatogr. B, 2012, 883-884, 33-49. (read article)

M. Briki et al., J. Chromatogr. B, 2024, 124039. (read article)

M. H. Quernin et al., J. Chromatogr. B Biomed. Sci. Appl., 2001, 763, 61-69. (read article)

D. R. Bunch et al., J. Chromatogr. B: Anal. Technol. Biomed. Life Sci., 2010, 878, 3255-3258. (read article)

M. Rauh et al., Clin. Pharmacokinet., 2006, 45, 305-316. (read article)

R-L. Chen et al., Pharmaceuticals (Basel), 2021, 14, 613. (read article)

[D8]-Busulfan

Purchase [D8]-Busulfan

Get a quote on this product

Related products