Stable isotope

Nucleosyn provides Custom Stable Isotope (²H, ¹³C, ¹⁵N) compounds to support projects dedicated to : Bioanalytics, Omics research, Molecular Imaging, and Biomarker discovery.

[D9]-C16-Sphingomyelin (d18:1/16:0)

CAS #

N/A

Packing size

1mg, 5mg, 25mg, bulk

Synonyme(s)

[D9]-C16-Sphingomyelin (d18:1/16:0) , [D9]-N-Palmitoyl-D-sphingomyelin, [D9]-(2S,3R,4E)-2-(Palmitoylamino)-4-octadecene-3-hydroxy-1-phosphocholine, [D9]-N-(Hexadecanoyl)-sphing-4-enine-1-phosphocholine, [D9]-N-Palmitoyl-D-erythro-sphingosylphosphorylcholine.

Stable Isotope Labelled Compound Sphingosines

C16 Sphingomyelin is a naturally occurring sphingolipid. Dysregulated sphingolipid metabolism has become a common theme in a variety of diseases, among which cancer and Alzheimer's disease (AD). For example, recent studies have suggested the potential utility of plasma sphingolipids as a diagnostic and/or prognostic indicator of AD.

Stable isotope Sphingomyelin (4LSC4211, [D9]-C16 Sphingomyelin) is intended for the quantification of C16-Sphingomyelin (4LSC3341) in biological matrices by GC or LC-MS.

Aspect

Solid

Purity

Chemical purity 95%; Isotopic Enrichment 98%

Solubility

chloroform, warm ethanol, warm methanol

Molecular weight

712,09

Molecular formula

C₃₉H₇₀N₂O₆D₉P

IUPAC

(2S,3R,E)-3-hydroxy-2-palmitamidooctadec-4-en-1-yl (2-(tris(methyl-d3)ammonio)ethyl) phosphate

W. Lin et al., Eur. J. Pharm. Sci., 2017, 105, 119-126. read article

A. N. Fonteh et al., Plos One, 2015, 10, 5, e0125597. read article

A. V. Alessenko, Biomeditsinskaya Khimiya, 2013, 59, 1, 25-50. read article

X. Han et al., Plos One, 2011, 6, 7, e21643. read article

M. M. Mielke, C. G. Lyketsos, Neuromolecular Med., 2010, 12, 4, 331-340. read article

M. Kosicek et al., Anal. Bioanal. Chem., 2010, 398, 7-8, 2929-2937. read article

M. M. Mielke et al., Neurobiol. Aging, 2010, 31, 1, 17-24. read article

V. R. Varma et al., Plos Med., 2018, 15, 1, e1002482. read article

J. Olazaran et al., J. Alzheimers Dis., 2015, 45, 4, 1157-1173. read article

A. N. Fonteh et al., Dis. Markers, 2006, 22, 1-2, 39-64. read article

[D9]-C16-Sphingomyelin (d18:1/16:0)

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