Stable isotope

Nucleosyn provides Custom Stable Isotope (²H, ¹³C, ¹⁵N) compounds to support projects dedicated to : Bioanalytics, Omics research, Molecular Imaging, and Biomarker discovery.

[D9]-Docetaxel

CAS #

940867-25-4

Packing size

5mg, 10mg, 25mg, bulk

Anticancer drug Therapeutic Drug Monitoring (TDM)

Docetaxel is an alkaloid used to treat numerous types of cancers, including breast cancer, head and neck cancer, stomach cancer, prostate cancer, and non-small-cell lung cancer. Docetaxel is cytotoxic and induces various severe side effects such as hair loss, low blood cell counts, allergic reactions, and future cancers.

Stable isotope labeled [D₉]-Docetaxel is intended for use as an internal standard for the quantification of Docetaxel by LC or GC-mass spectrometry.

Aspect

White solid

Purity

Chemical purity 95%; Isotopic Enrichment 98%

Solubility

DMSO

Molecular weight

816.94

Molecular formula

C₄₃H₄₄D₉NO₁₄

IUPAC

(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-4,6,11-trihydroxy-9-(((2R,3S)-2-hydroxy-3-((((2-(methyl-d3)propan-2-yl-1,1,1,3,3,3-d6)oxy)carbonyl)amino)-3-phenylpropanoyl)oxy)-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate

M. Briki et al., J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2024, 1236, 124039. (read article)

J. J. M. A. Hendrikx et al., Rapid Commun. Mass Spectrom., 2013, 27, 17, 1925-1934. (read article)

J. J. M. A. Hendrikx et al., J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2011, 879, 28, 2984-2990. (read article)

[D9]-Docetaxel

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