Synthetic lipids

NucleoSyn produces and supplies synthetic lipids from milligrams to multi-kilos quantities.

18:1 DAP

CAS #

127512-29-2

Packing size

100 mg, 500 mg, 1 g, bulk (gram scale)

Synonyme(s)

DODAP

siRNA delivery Nanoparticle

DODAP is an ionizable cationic lipid with lower cytotoxicity and high transfection efficiency. This compound is neutral at physiological pH, but acquires a positive charge inside the endosome due to the protonation of free amines when pH is lower than its pKa (<7). DODAP has been used as a component in liposomes that can be used to encapsulate siRNA, immunostimulatory oligodeoxynucleotides, antisense oligonucleotides, or chemotherapeutic agents for in vitro and in vivo delivery.

Aspect

Oil

Purity

98%

Solubility

CHCl3, MeOH

Molecular weight

648,07

Molecular formula

C₄₁H₇₇NO₄

IUPAC

3-(dimethylamino)propane-1,2-diyl dioleate

M. J. Carrasco et al., Commun Biol., 2021, 4, 956. read article

Y. Granot, D. Peer, Semin. Immunol., 2017, 34, 68-77. read article

N. Pardi et al., Nat. Rev. Drug Discov., 2018, 17, 261 -279. read article

T. Herrington et al., J. Gene Med., 2009, 11, 11, 1048-1063. read article

U. Sahin et al., Nat. Rev. Drug Discov., 2014, 13, 759 -780. read article

S. Semple et al., Biochemimica et Biophysica Acta., 2001, 1510, 1, 152-166. read article

18:1 DAP

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