Synthetic lipids

NucleoSyn produces and supplies synthetic lipids from milligrams to multi-kilos quantities.

ALC-0315

CAS #

2036272-55-4

Packing size

100 mg, 500 mg, 1 g, bulk (gram scale)

mRNA delivery Nanoparticle

ALC-0315 is one of the components in the BNT162b2 (Pfizer-Biontech) vaccine against SARS-CoV-2. Administration of (SARS-CoV-2) mRNA in LNPs constructed from ALC-0315 induces the production of IgG that binds to the SARS-CoV-2 receptor-binding domain (RBD) in rhesus macaques.

Aspect

Colorless oil

Purity

98%

Solubility

DMSO, EtOH

Molecular weight

766,29

Molecular formula

C₄₈H₉₅NO₅

IUPAC

((4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl) bis(2-hexyldecanoate)

A. B. Vogel et al., Nature, 2021, 592, 7853, 283-289. read article

L. Schoenmaker et al., International Journal of Pharmaceutics, 2021, 601, 120586. read article

S. M. Moghimi, Mol. Ther., 2021, 29, 3, 898-900. read article

ALC-0315

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