Synthetic lipids

NucleoSyn produces and supplies synthetic lipids from milligrams to multi-kilos quantities.

ATX-001

CAS #

1777792-33-2

Packing size

100 mg, 500 mg, 1 g, bulk (gram scale)

Cationic lipid Transfection

ATX-001 and ATX-002 are lipids constructed from a SAR study to optimize physicochemical parameters resulting in good in vivo activity within a range of measured basicity (pKa = 6.0−6.6) and lipophilicity (cLogD = 10−14). ATX-001 is useful for the development of lipidoid nanoparticles for siRNA, mRNA, and vaccine delivery. ATX-002 is a lipid for RNA and vaccine delivery.

Aspect

Solid powder

Purity

98%

Solubility

DMSO

Molecular weight

695,10

Molecular formula

C₄₀H₇₄N₂O₅S

IUPAC

di((Z)-non-2-en-1-yl) 8,8'-((2-((2-(dimethylamino)ethyl)thio)acetyl)azanediyl)dioctanoate

K. Rajappan et al., J. Med. Chem., 2020, 63, 21, 12992-13012. read article

A. Balupuri et al., Eur. J. Med. Chem., 2018, 148, 397-409. read article

ATX-001

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