Synthetic lipids

NucleoSyn produces and supplies synthetic lipids from milligrams to multi-kilos quantities.

C12-200 (racemic)

CAS #

1220890-25-4

Packing size

100 mg, 500 mg, 1 g, bulk (gram scale)

mRNA delivery siRNA delivery

C12-200 is a branched-chain ionizable lipidoid. It has been used for the delivery of mRNA, siRNA, or self-amplifying RNA (saRNA). C12-200 is also used in lipid nanoparticules (LNPs).

Aspect

Yellowish oil

Purity

98%

Solubility

DMSO, EtOH

Molecular weight

1136,96

Molecular formula

C₇₀H₁₄₅N₅O₅

IUPAC

1,1'-((2-(4-(2-((2-(bis(2-hydroxydodecyl)amino)ethyl)(2-hydroxydodecyl)amino)ethyl)piperazin-1-yl)ethyl)azanediyl)bis(dodecan-2-ol)

K. J. Kauffman et al., Nano. Lett., 2015, 15, 11, 7300-7306. read article

A. K. Blakney et al., Gene. Ther., 2019, 26, 9, 363-372. read article

P. Khare et al., The AAPS Journal, 2021, 24, 8, 1-17. read article

F. DeRosa et al., Gene. Ther., 2016, 23, 10, 699-707. read article

C12-200 (racemic)

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