Synthetic lipids

NucleoSyn produces and supplies synthetic lipids from milligrams to multi-kilos quantities.

cKK-E12 (enantiopur)

CAS #

1847446-19-8

Packing size

100 mg, 500 mg, 1 g, bulk (gram scale)

Nanoparticle LNP

cKK-E12 has been used to deliver siRNA in mice, rats, and primates (ED50 = 0.002, 0.01, & 0.3 mg/kg respectively) and shows low toxicity. cKK-E12 was highly selective toward liver parenchymal cell in vivo.

Aspect

Yellowish oil

Purity

98%

Solubility

DCM, DMSO

Molecular weight

993,64

Molecular formula

C₆₀H₁₂₀N₄O₆

IUPAC

(3S,6S)-3,6-bis(4-(bis((R)-2-hydroxydodecyl)amino)butyl)piperazine-2,5-dione

Y. Dong, K. T. Love, J. R. Dorkin, D. G. Anderson, Proc. Natl. Acad. Sci. U.S.A., 2014, 111, 11, 3955-3960. read article

M. Z. C. Hatit et al., Nat. Nanotechnol., 2022, 17, 3, 310-318. read article

cKK-E12 (enantiopur)

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