Synthetic lipids

NucleoSyn produces and supplies synthetic lipids from milligrams to multi-kilos quantities.

Dlin-DMA

CAS #

871258-12-7

Packing size

100 mg, 500 mg, 1 g, bulk (gram scale)

DLin Nanoparticle

DLin-DMA and derivatives are cationic lipids for siRNA mRNA, and vaccine delivery. As example, administration of DLin-MC3-DMA based LNPs have delivered siRNA to reduced Factor VII levels or leukemic burden in mices. DLin-MC3-DMA can form nanoparticles that can encapsulate and deliver siRNA, mRNA, DNA or small molecules into the cytoplasm and represent the most advanced delivery platforms for systemic administration of active molecules.

Aspect

Colorless oil

Purity

98%

Solubility

DMSO, EtOH, MeOH

Molecular weight

616,07

Molecular formula

C₄₁H₇₇NO₂

IUPAC

N,N-dimethyl-2,3-bis(((9Z,12Z)-octadeca-9,12-dien-1-yl)oxy)propan-1-amine

J. Heyes, L. Palmer, K. Bremmer, I. MacLachlan, J. Control Release, 2005, 107, 2, 276-287. read article

T. Kuboyama et al., ACS Med. Chem. Lett., 2019, 10, 5, 749-753. read article

M. Jayaraman et al., Angew. Chem. Int. Ed. Engl., 2012, 51, 34, 8529-8533. read article

J. A. Kulkarni et al., Nanomedicine, 2017, 13, 4, 1377-1387. read article

S. C. Semple et al., Nat. Biotechnol., 2010, 28, 2, 172-176. read article

Dlin-DMA

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