Synthetic lipids

NucleoSyn produces and supplies synthetic lipids from milligrams to multi-kilos quantities.

Dlin-KC2-DMA

CAS #

1190197-97-7

Packing size

100 mg, 500 mg, 1 g, bulk (gram scale)

DLin siRNA delivery

DLin-KC2-DMA and Dlin-KC3-DMA exhibited in vivo activity at siRNA doses as low as 0.6mg/kg and 0,01mg/kg respectively in rodents. DLin-KC2-DMA produces significant siRNA-mediated gene silencing of GAPDH, when binds to lipid nanoparticles (LNPs).

Aspect

Yellowish oil

Purity

98%

Solubility

DMSO, EtOH

Molecular weight

642,11

Molecular formula

C₄₃H₇₉NO₂

IUPAC

2-(2,2-di((9Z,12Z)-octadeca-9,12-dien-1-yl)-1,3-dioxolan-4-yl)-N,N-dimethylethan-1-amine

N. M. Belliveau et al., Molecular Therapy-Nucleic Acids, 2012, 1, e37/1-e37/9. read article

J. A. Kulkarni et al., ACS Nano, 2018, 12, 5, 4787–4795. read article

M. Jayaraman et al., Angew. Chem. Int. Ed. Engl., 2012, 51, 34, 8529-8533. read article

Dlin-KC2-DMA

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