
Synthetic lipids
NucleoSyn produces and supplies synthetic lipids from milligrams to multi-kilos quantities.
Dlin-KC2-DMA
CAS #
1190197-97-7
Packing size
100 mg, 500 mg, 1 g, bulk (gram scale)

DLin-KC2-DMA and Dlin-KC3-DMA exhibited in vivo activity at siRNA doses as low as 0.6mg/kg and 0,01mg/kg respectively in rodents. DLin-KC2-DMA produces significant siRNA-mediated gene silencing of GAPDH, when binds to lipid nanoparticles (LNPs).
Aspect
Yellowish oil
Purity
98%
Solubility
DMSO, EtOH
Molecular weight
642,11
Molecular formula
C43H79NO2
IUPAC
2-(2,2-di((9Z,12Z)-octadeca-9,12-dien-1-yl)-1,3-dioxolan-4-yl)-N,N-dimethylethan-1-amine
N. M. Belliveau et al., Molecular Therapy-Nucleic Acids, 2012, 1, e37/1-e37/9. read article
J. A. Kulkarni et al., ACS Nano, 2018, 12, 5, 4787–4795. read article
M. Jayaraman et al., Angew. Chem. Int. Ed. Engl., 2012, 51, 34, 8529-8533. read article