
Synthetic lipids
NucleoSyn produces and supplies synthetic lipids from milligrams to multi-kilos quantities.
Dlin-KC3-DMA
CAS #
1217306-46-1
Packing size
100 mg, 500 mg, 1 g, bulk (gram scale)

DLin-KC3-DMA is a lipid used for siRNA delivery. DLin-KC3-DMA and Dlin-KC2-DMA exhibited in vivo activity at siRNA doses as low as 0.6mg/kg and 0,01mg/kg respectively in rodents. DLin-KC2-DMA produces significant siRNA-mediated gene silencing of GAPDH, when binds to lipid nanoparticles (LNPs).
Aspect
Yellowish oil
Purity
98%
Solubility
DMSO
Molecular weight
656,14
Molecular formula
C44H81NO2
IUPAC
3-(2,2-di((9Z,12Z)-octadeca-9,12-dien-1-yl)-1,3-dioxolan-4-yl)-N,N-dimethylpropan-1-amine
J. A. Kulkarni et al., Nanomedicine, 2017, 13, 4, 1377-1387. read article
N. Jyotsana et al., Ann. Hematol., 2019, 98, 8, 1905-1918. read article
S. C. Semple et al., Nat. Biotechnol., 2010, 28, 2, 172-176. read article
G. Basha et al., Mol. Ther., 2011, 19, 12, 2186-2200. read article
J. B. Lee et al., Int. J. Cancer, 2012, 131, 5, E781-E790. read article