Synthetic lipids

NucleoSyn produces and supplies synthetic lipids from milligrams to multi-kilos quantities.

DOTAP

CAS #

132172-61-3

Packing size

100 mg, 500 mg, 1 g, bulk (gram scale)

Ammonium Nanoparticle

DOTMA and DOTAP are among the most widely used cationic lipids for gene transfection in vitro and in vivo. DOTMA and DOTAP carries a positive charge on the surface of liposomes which encapsulate siRNA, microRNAs, or oligonucleotides. DOTAP induces a positive charge on the liposomes and thus promotes efficient liposome- cell membrane interaction.

Aspect

Solid

Purity

98%

Solubility

EtOH, DMSO

Molecular weight

698,55

Molecular formula

C₄₂H₈₀ClNO₄

IUPAC

N,N,N-trimethyl-2,3-bis(oleoyloxy)propan-1-aminium chloride

C. Leal, N. F. Bouxsein, K. K. Ewert, C. R. Safinya, J. Am. Chem. Soc., 2010, 132, 47, 16841–16847. read article

A. Ahmad, H. M. Evans, K. Ewert, C. X. George, C. E. Samuel, C. R. Safinya, J. Gene Med., 2005, 7, 739-748. read article

Z. Chen, C. Meng, J. Mai, Y. Liu, H. Li, H. Shen, Acta Pharmaceutica Sinica B, 2023, 13, 3, 1274-1286. read article

DOTAP

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