Synthetic lipids

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Glucosylsphingosine / (GlSph)

CAS #

52050-17-6

Packing size

1mg, 5mg, 25mg, bulk

Synonyme(s)

GlcSph, D-Glucosylsphingosine

Biomarker Therapeutic Drug Monitoring (TDM)

Glucosylsphingosine (GlcSph) is a key biomarker of Gaucher Disease (GD). Glucosylsphingosine is a cytotoxic compound. Accumulation of glucosylsphingosine in brain and other tissues occurs in patients with Gaucher disease, which is an inherited deficiency of lysosomal glucocerebrosidase, which converts glucosylsphingosine to glucose and sphingosine.

Aspect

Solid

Purity

95%

Solubility

Ethanol, methanol, chloroform/methanol (2:1)

Molecular weight

461,64

Molecular formula

C₂₄H₄₇NO₇

IUPAC

(2R,3R,4S,5S,6R)-4-amino-2-(((2S,3R,E)-2-amino-3-hydroxyoctadec-4-en-1-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,5-diol

A. Rolfs et al., Plos One, 2013, 8, 11, e79732. read article

V. Murugesan et al., Am. J. Hematol., 2016, 91, 11, 1082-1089. read article

R. Hamler et al., Anal. Chem., 2017, 89, 16, 8288-8295. read article

Glucosylsphingosine / (GlSph)

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