Synthetic lipids

NucleoSyn produces and supplies synthetic lipids from milligrams to multi-kilos quantities.

Ionizable Ergosterol

Packing size

10 mg, 100 mg, 500 mg, bulk (gram scale)

Ionizable ergosterol is a newly developed sterol derivative designed for incorporation into the formulation of LNPs aimed at organ-selective mRNA delivery applications. While conventional four-component LNPs primarily deliver to the liver, the addition of ionizable ergosterol as a fifth component enables preferential delivery to the spleen or lungs. In ALC-0315-based LNPs, ionizable ergosterol allowed a remarkable selective spleen mRNA delivery up to 95%.

Nucleosyn promotes and provides high-quality novel synthetic compounds for R&D use only.

Related LNP components also provided by Nucleosyn: Cholesterol (non-animal), Ionizable Cholesterol, Ionizable 7-Dehydrocholesterol, Ionizable β-Sitosterol, Lipid U-101, ALC-0315

Aspect

White solid

Purity

98%

Solubility

DCM, Chloroform, THF

Molecular weight

726.06

Molecular formula

C₄₃H₇₁N₃O₆

C. Liu et al., ACS Appl. Mater. Interfaces, 2025, 17, 4416-4425. (read article)

Ionizable Ergosterol

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