Synthetic lipids

NucleoSyn produces and supplies synthetic lipids from milligrams to multi-kilos quantities.

Lipid 10A

Packing size

100 mg, 500 mg, 1 g, bulk (gram scale)

Lipid 10A is a novel ionizable lipid designed to improve the delivery efficiency of mRNA. The tetra-branched hydrophobic tail of Lipid 10A induced a higher stability of the corresponding LNPs and ensured the particle sizes’ uniformity. The introduction of the amino diethanol ionizable polar head allowed a suitable balance of the hydrophilicity/hydrophobicity of the LNPs, leading to an efficient mRNA delivery in both in vivo and in vitro experiments. As a first application, good results were obtained in the tumor growth prevention in B16-OVA melanoma models.

Nucleosyn promotes and provides high-quality novel synthetic lipids for R&D use only.

Related LNP components also provided by Nucleosyn: Lipid 8-O14B, Lipid N2-3L, DSPC, Cholesterol, DMG-PEG2000

Aspect

Colorless oil

Purity

98%

Solubility

DCM, Chloroform, MeOH, EtOH, Acetone

Molecular weight

923.55

Molecular formula

C₅₇H₁₁₄N₂O₆

IUPAC

bis(2-decyldodecyl) 3,3'-((3-(bis(2-hydroxyethyl)amino)propyl)azanediyl)dipropionate

H. Xu et al., Chin. Chem. Lett., 2025, 110883. (read article)