Synthetic lipids

NucleoSyn produces and supplies synthetic lipids from milligrams to multi-kilos quantities.

Lipid ND-01

Packing size

100 mg, 500 mg, 1 g, bulk (gram scale)

Synonyme(s)

ND-01

Liposome mRNA delivery

Lipid ND-01, also known as ND-01, is a novel ionizable lipid, derived from well-known Lipid 5, bearing an ether function on its linear hydrophobic tail. The Lipid ND-01-based nanoparticles (LNP-01) allowed a better HSP47 silencing than the Lipid 5-based LNPs in treating liver fibrosis in mice. In terms of the delivery of the bio-active substance, Lipid ND-01 induced a fast accumulation in the liver of the corresponding LNPs as well as a great cell uptake rate, leading to an improved siRNA delivery.

Nucleosyn promotes and provides high-quality novel synthetic lipids for R&D use only.

Related LNP components also provided by Nucleosyn: Lipid 5, DSPC, Cholesterol, DMG-PEG2000, [¹³C₃]-Lipid 5, Lipid ND-02, Lipid ND-03

Aspect

Colorless oil

Purity

98%

Solubility

DCM, Chloroform, MeOH, EtOH, Acetone

Molecular weight

712.15

Molecular formula

C₄₃H₈₅NO₆

IUPAC

heptadecan-9-yl 8-((8-(2-(hexyloxy)ethoxy)-8-oxooctyl)(2-hydroxyethyl)amino)octanoate

R. Chu et al., Int. J. Pharm., 2025, 671, 125192. (read article)