Synthetic lipids

NucleoSyn produces and supplies synthetic lipids from milligrams to multi-kilos quantities.

OH-Chol

CAS #

191173-82-7

Packing size

100 mg, 500 mg, 1 g, bulk (gram scale)

LNP Transfection

OH-Chol is a cationic cholesterol derivative. It has been used in cationic nanoparticles in combination with Tween 80 to transfect pDNA and siRNA into mouse xenograft model for intratumoral gene delivery.

Aspect

Crystalline solid

Purity

98%

Solubility

DMF, EtOH, DMSO

Molecular weight

500,81

Molecular formula

C₃₂H₅₆N₂O₂

IUPAC

(3S,8S,9S,10R,13R,14S,17R)-N-(2-((2-hydroxyethyl)amino)ethyl)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3-carboxamide

Y. Hattori et al., J. Drug Target, 2019, 27 (2), 217-227. read article

Y. Hattori, Z. Yakugaku, Pharm. Soc. Japan, 2010, 130 (7), 917-923. read article

OH-Chol

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