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DNA-RNA

Nuleosyn offers an extensive line of standard phosphoramidites, RNA phosphoramidites, specialty amidites and modifiers, solid supports CPG, reagents and solvents for a wide variety of instruments

5'-ODMT-Bz-difluoro-deoxycytidine

CAS #
142808-44-4
Packing size
100µmol, 250mg
Synonyme(s)
dFdC phosphoramidite
PhosphoramiditeDNA & RNA SupportsDNA & RNA NucleosidesDNA & RNA Analogs
5'-ODMT-Bz-difluoro-deoxycytidine Image 1

dFdC phosphoramidite, also known as Gemcitabine 3'-CE phosphoramidite, is a nucleoside phosphoramidite used in oligonucleotide synthesis. A chemical oligonucleotide synthesis instead of an enzymatic one allows quick access to bespoke oligonucleotides of the desired sequence. Chemically synthesised oligonucleotide sequences are typically constructed in a 3’ to 5’ direction. Gemcitabine 3'-CE phosphoramidite has been used in the synthesis of an oligonucleotide by single replacement of cytidine for gemcitabine for use in gene silencing experiments.

Aspect
white powder
Purity
>95% (LC)
Solubility
Dichloromethane, EtOAc, MeCN
Molecular weight
869,90
Molecular formula

C46H50F2N5O8P

IUPAC
(2R,3R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4,4-difluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

F. C. Richardson, K. K. Richardson, J. S. Kroin, L. W. Herte, Nucleic Acids Research, 1992, 20, 7, 1763-1768. read article

Y. Ma, Q. Mou, L. Zhu, Y. Su, X. Jin, J. Feng, D. Yan, X. Zhu, C. Zhang, Chem. Commun., 2019, 55, 6603-6606. read article

M. Sierant, M. Sobczak, M. Janicka, A. Paduszynska, D. Piotrzkowska, New J. Chem., 2010, 34, 918–924. read article

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