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5’-Phosphorylating Reagent II

CAS #

171285-25-9

Packing size

100µmol, 250mg

Synonyme(s)

CPRII

Phosphoramidite DNA & RNA Supports

Chemical phosphorylation reagent for the synthesis of 5'-phosphorylated oligonucleotides. The reagent contains a DMT group in its structure, which allows oligonucleotide purification by reversed-phase chromatography.

Aspect

Colorless semisolid

Purity

>95% (LC)

Solubility

MeCN

Molecular weight

722.82

Molecular formula

C₃₉H₅₁N₂O₉P

IUPAC

diethyl 2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-2-((((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)methyl)malonate

R. Hili, J. Niu, D. R. Liu, J. Am. Chem. Soc., 2013, 135, 1, 98–101. read article

T. Masuda, S. Kimura, M. M. Masud, H. Ozaki, Lett. Org. Chem., 2019, 16, 2, 122-127. read article

A. Guzaev, H. Salo, A. Azhaev, H. Lönnberg, Tetrahedron, 1995, 51, 34, 9375-9384. read article

5’-Phosphorylating Reagent II

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