
DNA-RNA
Nuleosyn offers an extensive line of standard phosphoramidites, RNA phosphoramidites, specialty amidites and modifiers, solid supports CPG, reagents and solvents for a wide variety of instruments
Amino-Modifier C6 dT
CAS #
178925-21-8
Packing size
100µmol, 250mg
Synonyme(s)
C6 dT

Sequence Modifiers are designed for use in automated synthesis. The carboxy-dT is hydrolyzed during deprotection and can be coupled directly to a molecule containing a primary amino group by a standard peptide coupling or via the intermediate N-hydroxysuccinimide (NHS) ester.
Aspect
White powder
Purity
>95% (LC)
Solubility
MeCN
Molecular weight
995.05
Molecular formula
C50H62F3N6O10P
IUPAC
(2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-5-((E)-3-oxo-3-((6-(2,2,2-trifluoroacetamido)hexyl)amino)prop-1-en-1-yl)-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
P. Kocalka, A. H. El-Sagheer, T. Brown, ChemBioChem, 2008, 9, 1280-1285. read article
C. Guo, C. P. Watkins, R. Hili, J. Am. Chem. Soc., 2015, 137, 34, 11191–11196. read article