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Amino-Modifier C6 dT

CAS #

178925-21-8

Packing size

100µmol, 250mg

Synonyme(s)

C6 dT

DNA & RNA Supports DNA & RNA Nucleosides

Sequence Modifiers are designed for use in automated synthesis. The carboxy-dT is hydrolyzed during deprotection and can be coupled directly to a molecule containing a primary amino group by a standard peptide coupling or via the intermediate N-hydroxysuccinimide (NHS) ester.

Aspect

White powder

Purity

>95% (LC)

Solubility

MeCN

Molecular weight

995.05

Molecular formula

C₅₀H₆₂F₃N₆O₁₀P

IUPAC

(2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-5-((E)-3-oxo-3-((6-(2,2,2-trifluoroacetamido)hexyl)amino)prop-1-en-1-yl)-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

P. Kocalka, A. H. El-Sagheer, T. Brown, ChemBioChem, 2008, 9, 1280-1285. read article

C. Guo, C. P. Watkins, R. Hili, J. Am. Chem. Soc., 2015, 137, 34, 11191–11196. read article

Amino-Modifier C6 dT

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