DNA & RNA
Nuleosyn offers an extensive line of standard phosphoramidites, RNA phosphoramidites, specialty amidites and modifiers, solid supports CPG, reagents and solvents for a wide variety of instruments.
Nucleosyn offers an extensive line of standard phosphoramidites, RNA phosphoramidites, specialty amidites and modifiers, solid supports CPG, reagents, and solvents for a wide variety of instruments. Customized products, such as special phosphoramidites, modifiers and linkers can be provided as well. For example, we propose a comprehensive line of high quality 5’-internal and 3’-amino modifiers, 5’-and 3’-thiol modifiers, 5’- and 3’-phosphorylating modifiers, 5’ and internal-biotin or fluorescein labelling. All CPG supports use the standard long chain alkylamino (lcaa) linker but differ in the glass pore size, 500Å or 1000Å. All CPG supports are fully end-capped to ensure that the CPG surface is totally inert. We also propose a wide selection of fluorophores and fluorescence quenchers which can be added during oligonucleotide synthesis at the 5’- or 3’-terminus or within the sequence. The resultant fluorescent oligonucleotide probes are typically used in a wide variety of applications like genetic and genome analyses, and forensic analysis.
Quality is our continuous concern. All our products are prepared under strict and detailed operating procedures.
- Each product, solvent or formulation is purified to meet most stringent specifications. Minor impurities, known to affect the yield of DNA & RNA synthesis, are eliminated through chemical and physical treatments.
- Phosphoramidites are tested for high performances. Each batch is individually analyzed to meet duly validated Standard Operating Procedures.
- To ensure maximum shelf-life, containers are filled under inert atmosphere and water content is kept at minimum workable levels. Typical water content of less than 10 ppm is available for Acetonitrile Diluent, ensuring improved yields throughout critical steps.
- Solutions are micro-filtered through 0.2 µm membranes.
- Certificates of Analysis detailing results of our Quality Control testing are delivered with each product.
- Custom synthesis, formulation and packaging can be discussed under complete confidentiality.