Synthetic lipids

NucleoSyn produces and supplies synthetic lipids from milligrams to multi-kilos quantities.

Well-characterized, these synthetic lipids are identical to their natural analogs and are well-defined, free of other lipids, non-lipids, bacterial/viral contamination. Nucleosyn developed extensive experience and in-depth know-how in the R&D of new lipid-based products, high quality phospholipids and other related compounds that are increasingly used as key substances (excipients, critical materials etc.) in drug formulations, drug delivery or manufacturing active pharmaceutical ingredients (APIs). Synthetic lipids play an important role as transfection agents. One of the most famous examples is the transfection of mRNA by LNP (Lipid NanoParticules) which is the technology of modern vaccines such as the COVID-19. Nucleosyn offers in its catalog most of the lipids that could be used for transfection of nucleic acids and we have developed an expertise in the synthesis of cationic ionizable lipids (DLin-MC3-DMA, C12-200…), cationic permanently charged lipids (DOTAP, DOTMA…), and also other structural and/or helper lipids (DSPC, DOPE, Cholesterol derivatives…).