PEG lipids
PEG lipids, also known as PEGylated lipids, are PEG derivatives linked to a lipid moiety. These compounds are used to improve the circulation time of the LNPs and reduce non-specific uptakes. PEG lipids have multiple effects, such as ALC-0159 (4LSC4952), also categorized as a helper lipid, which is a non-ionic surfactant. It contains a PEG chain of 45 to 46 units and has been used in the Pfizer-BioNTech SARS-CoV-2 mRNA vaccine.
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Ionizable lipids Cationic lipids Helper lipids PEG lipids Cholesterol derivatives Isotope-labeled lipids Sphingolipids
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PEG 2000 PE (18:1)
PEG2000 PE (18:1) can be used in the lipid bilayer preparation. This polyethyleneglycol/phosphatidyl-ethanolamine conj...
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PEG 2000 PE (18:0)
PEG 2000 PE (18:0) is used in combination with other phospholipids for drug delivery. PEG 2000 PE (18:0) is known to p...
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DMG-PEG 2000
DMG-PEG 2000 is a synthetic lipid excipient synthesized by PEGylation of myristoyl diglyceride. DMG-PEG 2000 is used i...
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ALC-0159
ALC-0159 is a lipid excipient. It has been deployed in the Pfizer-BioNTech SARS-CoV-2 mRNA vaccine in addition to ALC-...