Cholesterol derivatives
Cholesterol derivatives can be combined with cationic lipids to form cationic liposomes. These liposomes are used as intracellular delivery nanocarriers for nucleic acids, as well as pRNA and siRNA for intratumoral gene delivery. In addition, the incorporation of cholesterol in lipid nanoparticles (LNPs) improves intracellular delivery and LNP stability in vivo.
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Ionizable lipids Cationic lipids Helper lipids PEG lipids Cholesterol derivatives Isotope-labeled lipids Sphingolipids
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Cholesterol (nonanimal)
Synthetic cholesterol, known as a helper lipid, has been used in the formulation of lipid nanoparticles (LNPs) to impr...
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DC-Chol HCl
DC-cholesterol can be combined with DOPE (850725) to form cationic liposomes that can be used as intracellular deliver...
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OH-Chol
OH-Chol is a cationic cholesterol derivative. It has been used in cationic nanoparticles in combination with Tween 80 ...