Ionizable lipids
Ionizable lipids bear an ionizable polar head which is protonated at low pH but remains neutral under physiological pH. That pH-sensitivity is beneficial for nucleic acids delivery in vivo and improves the biocompatibility of ionizable lipids. Indeed, neutral lipids have fewer interactions with the anionic membrane of blood cells, which contributes to reducing the toxicity of lipid nanoparticles (LNPs). These properties make ionizable lipids highly suitable for transfection and drug delivery applications.
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Ionizable lipids Cationic lipids Helper lipids PEG lipids Cholesterol derivatives Isotope-labeled lipids Sphingolipids
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Lipid-29d
Lipid-29d is a novel ionizable lipid containing a thiophene moiety (Thio-lipid). The pH-response profile of this thio-...
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Lipid-20b
Lipid-20b is a novel ionizable lipid containing a thiophene moiety (Thio-lipid). The pH-response profile of this thio-...
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[13C3]-Lipid 5
Lipid H (SM102) and Lipid 5 were used for the delivery of mRNA in primates and rapidly cleared from the body resulting...
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[D13]-DLin-MC3-DMA
DLin-MC3-DMA is a cationic lipid for siRNA mRNA, and vaccine delivery. Administration of DLin-MC3-DMA-based LNPs have ...
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[13C3]-DLin-MC3-DMA
DLin-MC3-DMA is a cationic lipid for siRNA mRNA, and vaccine delivery. Injection of DLi...
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Lipid 29
Lipid 29 is an ionizable amino lipid (pKa = 6.91). Lipid 29 is used in combination with other lipids for the formulati...
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LP-01
LP-01 is a novel biodegradable (via labile ester linkages) and ionizable lipid that has been used in combination with ...
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ALC-0159
ALC-0159 is a lipid excipient. It has been deployed in the Pfizer-BioNTech SARS-CoV-2 mRNA vaccine in addition to ALC-...
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306Oi10
306Oi10 is a biodegradable, branched chain lipidoid. 306Oi10 has been used to co-deliver three mRNAs (firefly luc...
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ALC-0315
ALC-0315 is one of the components in the BNT162b2 (Pfizer-Biontech) vaccine against SARS-CoV-2. Administration of (SAR...