Ionizable lipids
Ionizable lipids bear an ionizable polar head which is protonated at low pH but remains neutral under physiological pH. That pH-sensitivity is beneficial for nucleic acids delivery in vivo and improves the biocompatibility of ionizable lipids. Indeed, neutral lipids have fewer interactions with the anionic membrane of blood cells, which contributes to reducing the toxicity of lipid nanoparticles (LNPs). These properties make ionizable lipids highly suitable for transfection and drug delivery applications.
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Ionizable lipids Cationic lipids Helper lipids PEG lipids Cholesterol derivatives Isotope-labeled lipids Sphingolipids
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Lipid U-101
Lipid U-101 is a newly developed ionizable synthetic lipid designed for incorporation into the formulation of LNPs as ...
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Lipid 8-O14B
Lipid 8-O14B is a bioreducible lipid designed for conceiving specific nanoparticles (nanocomplexes) dedicated to effic...
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Lipid 10A
Lipid 10A is a novel ionizable lipid designed to improve the delivery efficiency of mRNA. The tetra-branched hydrophob...
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Lipid ND-03
Lipid ND-03 is a novel ionizable lipid, derived from well-known Lipid 5, bearing an ether function on its linear hydro...
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Lipid ND-02
Lipid ND-02 is a novel ionizable lipid, derived from well-known Lipid 5, bearing an ether function on its linear hydro...
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Lipid ND-01
Lipid ND-01, also known as ND-01, is a novel ionizable lipid, derived from well-known Lipid 5, bearing an ether functi...
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Lip-CD
Lip-CD is a novel lipidic cyclodextrin used in combination with Lipid N2-3L (also provided by Nucleosyn) in the concep...
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L-PGTA
L-PGTA is a new poly-ionizable lipid-modified poly(guanidine thioctic acid) polymer developed to enhance the efficienc...
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Lipid N2-3L
Lipid N2-3L is a novel ionizable lipid used in combination with other lipids, such as L-PGTA also provided by Nucleosy...
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Lipid-29d
Lipid-29d is a novel ionizable lipid containing a thiophene moiety (Thio-lipid). The pH-response profile of this thio-...